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2,000 Human Brains Yield Clues to How Genes Raise Risk for Mental Illnesses

National Institutes of Health
December 19, 2018

It’s one thing to detect sites in the genome associated with mental disorders; it’s quite another to discover the biological mechanisms by which these changes in DNA work in the human brain to boost risk. In their first concerted effort to tackle the latter, 15 collaborating research teams of the National Institutes of Health-funded PsychENCODE Consortium leveraged statistical power gained from a large sample of about 2000 postmortem human brains.

The teams published their findings in seven research articles, spotlighted on the cover of a “psychiatric genomics” special issue of Science — along with two in Translational Medicine and one in Science Advances — on Dec. 14, 2018. In addition, the consortium is sharing their data with the research community via the online PsychENCODE Knowledge Portal.